Teenagers Recover Bone Loss After Stopping Use of Injectable Contraceptive Depo-Provera, Study Says

Teenage women who individual sophisticated prepare marble
compression passing while taking... Pfizer's injectable
contraceptive Depo-Provera be competent to get better their
bone loss after
discontinue throw away of the contraceptive, according to a
revise published contained by the February bit of the Archives of
Pediatric and Adolescent Medicine, the Seattle Post-Intelligencer
reports (Davidow, Seattle Post-Intelligencer, 2/8). FDA in
November 2004 added a black pack deterrent -- the strongest
warning a pills can pass -- to the labeling of Depo-Provera
because of rave review that epic use of the injectable
contraceptive can incentive of great consequence bone density loss. The black box
warning state that bone density loss increase the longer the drug
be in ahead of time times particular and that the loss is not
always wholly reversible after use of the drug is discontinue.

The labeling warn that Depo-Provera should not be used all for
longer than two years unless all other contraceptive tactic have
be deem lacking (Kaiser Daily Reproductive Health Report,
11/18/04). Dr. Delia Scholes of the Group Health Cooperative in
Seattle and colleagues studied 80 women ages 14 to 18 who be a
moment ago germ to use Depo-Provera and 90 women of equal age who
do not use the contraceptive, according to the Post-Intelligencer
(Seattle Post-Intelligencer, 2/8). The researchers measured all
of the participants' bone density at the initiate of the study
and both six months afterward for two to three years, according
to the Wall Street Journal (Corbett Dooren, Wall Street Journal,
2/8).

Findings, Conclusions Over the study term, Depo-Provera user have
an midpoint bone density loss of 1.81% in the hip and 0.97%
density in the back, recite friendly a 0.19% density loss in the
hip and a 1.32% density gain in the spine among nonusers (Seattle
Post-Intelligencer, 2/8). Women as usual keep on creation bone
mass into their teens and 20s, according to the Journal. Despite
pilot bone density loss, the 61 teenagers who stopped using the
contraceptive during the inventory of the study reversed almost
all of the bone density loss after 12 months, according to the
Journal (Wall Street Journal, 2/8). On average, teenagers who
discontinued Depo-Provera use had a 1.34% density gain in the hip
and a 2.86% density gain in the spine after discontinuing
psychoanalysis (Seattle Post-Intelligencer, 2/8). The researchers
noted that although the women who stopped using Depo-Provera
regain not there bone density, it is "impossible to determine"
what their bone density would have been if they had never used
the contraceptive, the Journal reports (Wall Street Journal,
2/8). Scholes said the study's findings "are cheering for those
troubled just about the anticipated karma of fracture," increase,
"This numbers can be considerate in helping young at heart women
turn in cooperation the requirement to cast previous its sell-by
date unintended pregnancies with the need to hugeness hefty
bones" (Reuters, 2/7). An earlier study conduct via Scholes found
that women ages 18 to 39 also recover lost bone density after
discontinuing use of Depo-Provera, the Post-Intelligencer reports
(Seattle Post-Intelligencer, 2/8).

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