Thursday, March 20, 2008

Single Radiation Dose Causes 30% Loss Of Spongy Bone In Mice - Study Has Implications For Radiation Therapy, Deep Space Travel




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"We be really dazed at the level of bone demise," said front
pollster Ted A. Bateman of Clemson University. "We're seeing
bone loss at
substantially degrade dose of radiation than we anticipated." The
mice suffer the loss of trabecular bone, the spongy area of bone
in the quarters the frayed outer area agreed by process of the
cortical bone.



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"A murine prototype for bone loss from therapeutic
and space-relevant cause of radiation," by Sarah A. Hamilton,
Neil D. Travis, Jeffrey S. Willey, Eric R. Bandstra and Ted A.
Bateman, Clemson University; and Michael J. Pecaut, Daila S.
Gridley and Gregory A. Nelson, Loma Linda University and Medical
Center, appears in the online edition of the Journal of Applied
Physiology, published by The American Physiological Society .



Mouse model apply to human The grades of a mouse study cannot be
precisely applied to humans. However, both mice and humans unload
in the fabricated position bone after radiation display, in view
of that the results elevate a red ensign. Bateman noted that a
recent clinical study of 6,000 cancer patients reported in the
Journal of the American Medical Association found that
post-menopausal women who received pelvic radiation for cervical
and colorectal cancer increased their bone fracture question by
60%. Radiation uninterrupted anal cancer increased the risk of
fracture by 200%, he said.



Astronauts lose 2% of bone mass apiece month they be shown to the
effects of microgravity. So far, astronauts have not be exposed
to the increased radiation of outer space, but that will change
when they attempt a proposed 30-month slump to Mars, Bateman
said. NASA has persistent on radiation's cancer-causing ram and
its shrewdness to compromise the central like a cat on baking
bricks and immune group. But the effect on bone form be an
unexamined neighbourliness.



The murine (mouse) model such as the one here study provide a
bearing to study the physiological effects of radiation using
controlled experiment. Clinical studies of family who put up
beside radiation to overwork cancer are fixed because of the
complicate factor of the illness itself and the chemotherapy
which typically accompany it. "You can't study this in people, so
have a well-defined animal model is great," Bateman said.



Study focus on four like of radiation In the contemporary study,
the mice received a spinster 2 Gray (Gy) dose, which is
comparable to the single dose of 1-2 Gy that human cancer
patients receive. However, cancer patients receive a cable of
doses ended the stock of therapy, totaling 10-70 Gy. (The amount
of radiation in a Gy come and walk, because it is calculated end
on the recipient's weight.) The mice were divided into five
group. The adjust mixture received no radiation. Each of the
remaining four groups received a differing type of radiation:
gamma, proton, ion or carbon.



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Source "A murine model for bone loss from therapeutic and
space-relevant sources of radiation," by S.A. Hamilton, N.D.
Travis, J.S. Willey and T.A. Bateman, Department of
Bioengineering, Clemson University, Clemson, South Carolina; M.J.
Pecaut, D.S. Gridley and G.A. Nelson, department of Radiation
Medicine, Loma Linda University and Medical Center, Loma Linda,
California, appears in the online edition of the Journal of
Applied Physiology published by The American Physiological
Society.



Bateman's troop received the mouse bones from the Loma Linda
group, which have nearly untried the mice to examine the effects
of radiation on the immune system.



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The American Physiological Society be found in 1887 to foster
poor and applied bioscience. The Bethesda, Maryland-based society
has 10,500 member and publish 14 peer-reviewed account enclose
almost 4,000 article annually. APS provides a colossal range of
research, on a winning streak and work support and programming to
further the contributions of physiology to concerned the
apparatus of diseased and forceful state. In 2004, APS received
the Presidential Award for Excellence in Science, Mathematics and
Engineering Mentoring (PAESMEM).



The American Physiological Society 9650 Rockville Pike, Bethesda,
MD 20814; Tel: (301) 634-7253





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